The “eye”-series fulfil the gap between ex vivo biodistributions and advanced m
ultimodal imaging systems. Planar mode is the most efficient method for fast in vivo screening of various biomolecules and this is what the “eyes” offer
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5 + 1 THINGS YOU DIDN’T KNOW YOU COULD DO WITH THE “EYES”
1. Have a full biodistribution data set, for all time points post injection, non-invasively, using only one animal.
- Ηaving the same animal for all time-points, significantly improves statistics and accuracy of studies, while minimizing the number of required animals per study.
- Efficient animal use significantly reduces cost, as well as time required to understand how a new product behaves, thus enabling the testing of different product variations.
- The “eyes” can be used as a quality assurance tool of the biodistribution test sample, identifying bad injections or animals with “unexpected” behavior before proceeding to the ex-vivo study.
- By using fewer animals, groups performing biodistributions can easily comply with bio-ethical standards and the 3Rs Principle by significantly reducing number of animals used.
2. Obtain whole body images easily, right from the first second post injection.
3. Speed up ex-vivo biodistributions by imaging all organs in a single view.
4. Provide semi-quantitative planar images of significantly higher resolution, with no penetration depth limit at a much lower cost compared to optical imaging.
5. Optimize your imaging protocols by:
- defining the optimal time points to image;
- studying the effect of different preparation conditions;
- testing alternative administration routes;
- optimizing injected concentrations;
- dynamic imaging of the first minutes post injection.
6. Fully exploit an advanced multimodal imaging system by only scanning at the optimal times, tracers, conditions, animals:
- By first defining all the optimal parameters through the “eyes”, you can significantly reduce the cost, time and accuracy of conducted studies and ensure that no tomographic 3D scans goes discarded.